Ammonia reduces glutamine synthetase expression in astrocytes via activation of Hippo-YAP signaling pathways
Yusuke Nasu, Sari Kishikawa, Mamiko Imai, Nozomi Yokoyama, Izumi Iida, Koichi Tabeta, Miho Terunuma · 2025
Read Ammonia reduces glutamine synthetase expression in astrocytes via activation of Hippo-YAP signaling pathways by Yusuke Nasu, Sari Kishikawa, Mamiko Imai, Nozomi Yokoyama, Izumi Iida, Koichi Tabeta, Miho Terunuma (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12728173.txt.
Description
Yusuke Nasu and co-authors trace in 2025 how ammonia lowers a protective enzyme in the brain's support cells. The enzyme, made by astrocytes, clears two chemicals that excite nerve cells and can turn toxic in excess. Its loss is tied to disorders such as epilepsy, but the control system behind it was unclear.
The team found the enzyme's level is set by a gene activity booster called YAP, fed by two signal pathways. When ammonia rises, it switches on one pathway, which bars YAP from the cell nucleus and lets enzyme levels fall. In rodent epilepsy models, a drug that frees YAP kept enzyme levels up and shielded nerve cells from death. The authors name YAP a promising target for diseases where ammonia drags this enzyme down.
Catalog record
| CREATOR | Yusuke Nasu, Sari Kishikawa, Mamiko Imai, Nozomi Yokoyama, Izumi Iida, Koichi Tabeta, Miho Terunuma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |