Blastic plasmacytoid dendritic cell neoplasm secondary to acute myeloid leukemia with shared mutations in TET2 and DNMT3A: a case report and literature review
Yao Sun, Yingjie Liu, Na Liu, Xiaohui Zhang, Wenrong Huang, Liangding Hu · 2025
Read Blastic plasmacytoid dendritic cell neoplasm secondary to acute myeloid leukemia with shared mutations in TET2 and DNMT3A: a case report and literature review by Yao Sun, Yingjie Liu, Na Liu, Xiaohui Zhang, Wenrong Huang, Liangding Hu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12727995.txt.
Description
Yao Sun and five co-authors wrote a 2025 case report on a rare blood cancer arising after leukemia, with a review of similar cases. The second cancer, BPDCN, is an aggressive malignancy of plasmacytoid dendritic cells. It increasingly appears in patients with earlier myeloid cancers, suggesting shared roots.
Their patient developed BPDCN after acute myeloid leukemia, with marrow spread and signs pointing to the central nervous system. Gene testing found five mutations in the new cancer. Two of them, in TET2 and DNMT3A, were already present in the original leukemia, marking a shared clone. Reviewing ten published cases with clonal data, TET2 mutations appeared in nine. Some patients carried those clones years earlier in other blood conditions. The pattern casts TET2 as a founding driver of this cancer family.
Catalog record
| CREATOR | Yao Sun, Yingjie Liu, Na Liu, Xiaohui Zhang, Wenrong Huang, Liangding Hu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |