Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology
Che Chen, Qianfeng Shao, Sheng Zhou · 2025
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Description
Che Chen, Qianfeng Shao, and Sheng Zhou probe how a classical Chinese formula might act against Alzheimer's disease, starting in software. Their 2025 paper studies a three-herb decoction long used for other conditions. Databases of herbal chemistry yielded thirty-seven active ingredients and 230 targets; disease gene data yielded thousands of altered genes, and forty-seven targets sat in the overlap.
Modeling pointed to three core targets and two standout plant compounds that dock neatly onto them. The enriched pathways involved inflammation signals and calcium signaling, familiar Alzheimer's territory. Cell tests then gave the software something real to answer to. In nerve-like cells injured by an amyloid fragment, the two compounds and serum from treated animals restored survival almost fully. Key pathway proteins shifted in the predicted directions. The authors present the work as a mechanism sketch with early laboratory support, not a clinical claim.
Catalog record
| CREATOR | Che Chen, Qianfeng Shao, Sheng Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |