PARP7 and aryl hydrocarbon receptor differentially regulate mammary cancer cell proliferation and STING-induced type I interferon signalling
Ninni E Olafsen, Samaneh S Åhrling, Marit Rasmussen, Linnea A M Erlingsson, Emma N Granly, Akinori Takaoka, Jason Matthews · 2025
Read PARP7 and aryl hydrocarbon receptor differentially regulate mammary cancer cell proliferation and STING-induced type I interferon signalling by Ninni E Olafsen, Samaneh S Åhrling, Marit Rasmussen, Linnea A M Erlingsson, Emma N Granly, Akinori Takaoka, Jason Matthews (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12727882.txt.
Description
Ninni Olafsen and co-authors study two regulators of cell growth and immune signalling in mouse breast cancer cells, in work published in 2025. One regulator, PARP7, dampens both interferon signalling and a sensor pathway called AHR. A drug that blocks PARP7 slows some cancer lines, but the roles of the two pathways in that effect were unclear.
The team treated two mouse mammary cancer lines with sensor activators, the blocking drug, and a STING activator that raises interferon. The drug boosted both pathways in both lines. Only one line slowed its growth on the drug alone, and it died by a self-destruct programme. The resistant line slowed only when the STING activator joined the drug, and losing the sensor deepened the effect. The authors show the two regulators act differently by cell line.
Catalog record
| CREATOR | Ninni E Olafsen, Samaneh S Åhrling, Marit Rasmussen, Linnea A M Erlingsson, Emma N Granly, Akinori Takaoka, Jason Matthews |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |