Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming
Xiaodi Fu, Fangqi Peng, Ruyi Cai, Jingping Mao, Tianxing Liu, Yingshuai Dong, Ruoqi Cheng, Zhihan Yang, Guanxian Chen, Cheng Li, Rong Mu, Lin Cheng, Yanglu Wang, Jingyang Guan, Hongkui Deng · 2025
Read Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming by Xiaodi Fu, Fangqi Peng, Ruyi Cai, Jingping Mao, Tianxing Liu, Yingshuai Dong, Ruoqi Cheng, Zhihan Yang, Guanxian Chen, Cheng Li, Rong Mu, Lin Cheng, Yanglu Wang, Jingyang Guan, Hongkui Deng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12727690.txt.
Description
Xiaodi Fu and co-authors describe a way to make stem cells from human blood in this 2025 paper. These cells can renew themselves and can be turned into many cell types for a patient. Older methods rely on added genes and are costly, slow, and hard to scale. A chemical route, using small molecules, offers a simpler path.
The team builds on their past work with chemical reprogramming in mice and in human cells. Blood is easy to draw and store, so it suits large-scale use. Past blood methods, though, were not efficient or robust enough. The paper reports a robust route to cells suited for clinical use, which could support patient-specific cell therapies.
Catalog record
| CREATOR | Xiaodi Fu, Fangqi Peng, Ruyi Cai, Jingping Mao, Tianxing Liu, Yingshuai Dong, Ruoqi Cheng, Zhihan Yang, Guanxian Chen, Cheng Li, Rong Mu, Lin Cheng, Yanglu Wang, Jingyang Guan, Hongkui Deng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |