Skewed pulmonary innate immune cell composition underlies the delayed influenza clearance in aged mice
Xiaoyang Cheng, Fang Zhao, Jing Wu, Yanmin Wan, Zhaoqin Zhu, Jialin Jin · 2025
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Description
Older people clear flu from their lungs more slowly than younger adults, and Xiaoyang Cheng and co-authors probe why using mice. Adult mice of eight to twelve months and aged mice of twenty-two to twenty-four months received a mild dose of H1N1 flu. The team tracked weight, virus levels in the lungs, and the mix of front-line immune cells there.
Both groups lost similar weight, yet the aged mice still carried much more virus on day eight. The cell mix differed by age in telling ways. In adults, one cell type, alveolar macrophages, tracked with less weight loss, while no cell type played that protective role in the aged group. Mice that kept the virus longer also showed age-specific cell patterns despite similar inflammation signals.
Catalog record
| CREATOR | Xiaoyang Cheng, Fang Zhao, Jing Wu, Yanmin Wan, Zhaoqin Zhu, Jialin Jin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |