Up-regulation of peripheral and central CGRP expression combined with subchondral bone remodeling in rat MIA-induced TMJOA model
Liqin Xu, Henghua Jiang, Qijun Xu, Wei Fang · 2025
Read Up-regulation of peripheral and central CGRP expression combined with subchondral bone remodeling in rat MIA-induced TMJOA model by Liqin Xu, Henghua Jiang, Qijun Xu, Wei Fang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12727174.txt.
Description
Liqin Xu, Henghua Jiang, Qijun Xu, and Wei Fang track a pain peptide through a rat jaw arthritis model. Their study from twenty twenty-five uses a chemical joint injury. Jaw osteoarthritis remodels the bone under the cartilage. How bone change connects to pain signalling was unclear.
Scans measured the subchondral bone degeneration directly. Staining counted the bone-eating cells active there. The peptide CGRP rose in the joint tissues. It also rose in nerve ganglia and pain centres. Even a memory-related brain region showed changes. Peripheral and central pain systems move together here. Joint pain may need treatment beyond the joint itself.
Catalog record
| CREATOR | Liqin Xu, Henghua Jiang, Qijun Xu, Wei Fang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |