Hyperlipidemia-associated specific modules and hub genes revealed by integrative methods of WGCNA and MetaDE
Zhiyi Zhao, Yin Cao, Anna Gu, Hanxin Yao · 2025
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Description
Zhiyi Zhao, Yin Cao, Anna Gu and Hanxin Yao search for gene modules and hub genes tied to hyperlipidemia, in this 2025 Europe PMC paper. Hyperlipidemia, high blood lipids, drives heart disease, and its key genes are still being mapped. The team combined two integrative methods on three public microarray datasets.
Network analysis found eleven gene modules linked to the condition, while a meta-analysis method found over a thousand differentially expressed genes. The overlap of a few hundred genes was used to build a protein interaction network. Four shared pathways emerged, covering immune cell engulfing, chemokine signaling, endocytosis and killer cell activity. Hub genes such as RAF1, GRK3 and CXCR2 stood out as candidate drivers.
Catalog record
| CREATOR | Zhiyi Zhao, Yin Cao, Anna Gu, Hanxin Yao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |