High expression of IQGAP3 promotes the infiltration of M0 macrophages into the TME, resulting in a poor prognosis for gastric cancer patients
Shurong Liu, Hongwei Zhang, Bignqi Dong, Xiaocong Pang, Yong Jiang, Guowei Chen, Yingchao Wu, Tao Liu, Changyou Wang, Junling Zhang, Xin Wang · 2025
Read High expression of IQGAP3 promotes the infiltration of M0 macrophages into the TME, resulting in a poor prognosis for gastric cancer patients by Shurong Liu, Hongwei Zhang, Bignqi Dong, Xiaocong Pang, Yong Jiang, Guowei Chen, Yingchao Wu, Tao Liu, Changyou Wang, Junling Zhang, Xin Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12724071.txt.
Description
Shurong Liu and co-authors present a 2025 study on a gene that worsens stomach cancer by drawing in immune cells. The gene, IQGAP3, runs high in gastric tumors. The team asked how it shapes the tumor's surroundings and patient outlook, using cancer databases and samples from 107 hospital patients.
Silencing the gene in two stomach cancer cell lines slowed growth, movement, and invasion. A signal molecule it controls, CXCL13, fell when the gene was cut, through two signaling switches. In mice, tumors with low gene levels recruited fewer immature macrophages, the immune cells tied to poor prognosis. Patients whose tumors ran high on the gene fared worse. The authors name the gene a driver and possible target.
Catalog record
| CREATOR | Shurong Liu, Hongwei Zhang, Bignqi Dong, Xiaocong Pang, Yong Jiang, Guowei Chen, Yingchao Wu, Tao Liu, Changyou Wang, Junling Zhang, Xin Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |