Skin cancer and hyperthermia and radiotherapy – SAHARA: study protocol for a multicenter, two-arm, open-label, randomized controlled phase II non-inferiority trial
Winfried Arnold, Maximilian Sturz, Nidar Batifi, Peter Vaupel, Markus Notter, Boris Mueller-Hübenthal, Emsad Puric, Stefan Brodmann, Daniel Zwahlen · 2025
Read Skin cancer and hyperthermia and radiotherapy – SAHARA: study protocol for a multicenter, two-arm, open-label, randomized controlled phase II non-inferiority trial by Winfried Arnold, Maximilian Sturz, Nidar Batifi, Peter Vaupel, Markus Notter, Boris Mueller-Hübenthal, Emsad Puric, Stefan Brodmann, Daniel Zwahlen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12723921.txt.
Description
Winfried Arnold and eight co-authors lay out a trial protocol for skin cancer treatment in a 2025 paper. Non-melanoma skin cancer is common in older, fair-skinned patients. Radiation is often chosen over surgery for large tumors or frail patients, but standard schedules bring real side effects.
The trial asks whether gentle heat can let doctors cut the radiation dose without losing control of the tumor. One hundred patients will be randomized: half get standard radiation, half get a milder infrared heating session right before a shorter, stronger-per-visit radiation course. The heating method uses water-filtered infrared light. The main measure is local control after two years, with the trial designed to prove the gentler arm is not worse by more than a set margin. If it succeeds, elderly patients could finish treatment in three weeks instead of four, with less skin damage.
Catalog record
| CREATOR | Winfried Arnold, Maximilian Sturz, Nidar Batifi, Peter Vaupel, Markus Notter, Boris Mueller-Hübenthal, Emsad Puric, Stefan Brodmann, Daniel Zwahlen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |