YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation
Da Zhong, Wenqing Xie, Zhan Liao, Hua Liu, Lemei Zhu, Fawei Gao, Xi Li, Zhen Yin, Ganzhe Xu, Peng Chen, Jian Tian, Long Wang, Ke Yin, Kunli Chen, Chenggong Wang · 2025
Read YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation by Da Zhong, Wenqing Xie, Zhan Liao, Hua Liu, Lemei Zhu, Fawei Gao, Xi Li, Zhen Yin, Ganzhe Xu, Peng Chen, Jian Tian, Long Wang, Ke Yin, Kunli Chen, Chenggong Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12723855.txt.
Description
Da Zhong and co-authors uncover a chain of defenses that keeps bone-building cells from a rust-like death around joint implants. Tiny titanium particles shed by implants provoke bone loss and loosening, a top cause of joint replacement failure. The death pathway, ferroptosis, is driven by iron and fat oxidation. The team studied it in tissue from patients and in mouse and cell models.
Ferroptosis ran high where particles attacked, and blocking it eased the bone loss. Two helper proteins were turned down in the damage zone. One switches on the gene for the other, which speeds up production of two shield proteins. A growth pathway sits above them, boosting the whole chain. Restoring any link protected bone cells. The authors offer the chain as a drug target to make implants last.
Catalog record
| CREATOR | Da Zhong, Wenqing Xie, Zhan Liao, Hua Liu, Lemei Zhu, Fawei Gao, Xi Li, Zhen Yin, Ganzhe Xu, Peng Chen, Jian Tian, Long Wang, Ke Yin, Kunli Chen, Chenggong Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |