Dual-functional nanovesicles simultaneously inhibit stromal fibrosis and angiogenesis to suppress cholangiocarcinoma progression
Lijing Zhang, Xixi Duan, Qiying Shi, Xiaohan Yao, Qiang Chen, Jiajia Wan, Fazhan Wang, Chen Ni, Yongjuan Li, Ming Wang, Yuqiao Sheng, Wenfu Zheng, Juan Liu, Tianjiao Ji, Zhihai Qin · 2025
Read Dual-functional nanovesicles simultaneously inhibit stromal fibrosis and angiogenesis to suppress cholangiocarcinoma progression by Lijing Zhang, Xixi Duan, Qiying Shi, Xiaohan Yao, Qiang Chen, Jiajia Wan, Fazhan Wang, Chen Ni, Yongjuan Li, Ming Wang, Yuqiao Sheng, Wenfu Zheng, Juan Liu, Tianjiao Ji, Zhihai Qin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12723841.txt.
Description
Lijing Zhang and co-authors design tiny vesicles that fight a bile duct cancer on two fronts, in a 2025 study. This cancer resists drugs that starve tumors of blood vessels. The team found why: those drugs wake support cells that lay down dense matrix. The matrix then shields the tumor from the drugs.
Their vesicles come from vessel lining cells and keep the receptors of their source. They soak up growth signals that feed new vessels. They also carry a peptide that quiets the support cells, guided by a targeting tag. One therapy thus cuts both vessel growth and scarring. The design was tested as a way to slow this hard cancer, which is the second most common primary liver cancer.
Catalog record
| CREATOR | Lijing Zhang, Xixi Duan, Qiying Shi, Xiaohan Yao, Qiang Chen, Jiajia Wan, Fazhan Wang, Chen Ni, Yongjuan Li, Ming Wang, Yuqiao Sheng, Wenfu Zheng, Juan Liu, Tianjiao Ji, Zhihai Qin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |