DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging
Xueyao Cai, Weidong Li, Wenjun Shi, Xia Ding, Yuchen Cai · 2025
Read DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging by Xueyao Cai, Weidong Li, Wenjun Shi, Xia Ding, Yuchen Cai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12723258.txt.
Description
A gene that tags proteins with fatty chains may also drive how fast a face ages. Xueyao Cai and four co-authors used genetic methods in 2025 to test whether the gene ZDHHC17 causes facial skin aging, and whether DNA methylation sits in the middle of that path.
Mendelian randomization, which uses gene variants as natural experiments, tied higher expression of the gene to greater facial aging risk in data from over 420,000 people. A second method confirmed the link. Mediation analysis then asked whether methylation marks on DNA steer the gene's expression, and so the aging. Sensitivity checks probed the result's sturdiness. The authors present the chain as a fresh angle on skin aging biology.
Catalog record
| CREATOR | Xueyao Cai, Weidong Li, Wenjun Shi, Xia Ding, Yuchen Cai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |