Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development
Md Amanat Ullah Arman, Md. Selim Reza, Muhammad Habibulla Alamin, Tasnia Akter Maya, Md. Tofazzal Hossain · 2025
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Description
Prostate cancer kills many men worldwide, and new drug targets are still needed for its advanced forms. Md Amanat Ullah Arman and co-authors hunted such targets with computing tools in this 2025 study. They merged three public data sets of gene activity in tumors. A standard analysis found 458 genes whose activity changed in all three sets.
Those genes were mapped into a network of protein partnerships. Fifteen hub genes sat at the network's busy centers. Five of the hubs, when quieter, tied to better patient survival, which makes them odd but telling leads. The team also screened for existing drugs that might be reused against the hubs. Computer-first hunts like this focus costly lab work on the most promising genes.
Catalog record
| CREATOR | Md Amanat Ullah Arman, Md. Selim Reza, Muhammad Habibulla Alamin, Tasnia Akter Maya, Md. Tofazzal Hossain |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |