Progressive Supranuclear Palsy With Post-traumatic Frontal Lobe Damage Mimicking Anti-IgLON5 Antibody Disease
Damla Ates Gulkok, Aiswarya Raj, Yakira Mishan, Jessica Bloom, Brittany Zaita, Robert Fekete · 2025
Read Progressive Supranuclear Palsy With Post-traumatic Frontal Lobe Damage Mimicking Anti-IgLON5 Antibody Disease by Damla Ates Gulkok, Aiswarya Raj, Yakira Mishan, Jessica Bloom, Brittany Zaita, Robert Fekete (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12723170.txt.
Description
Damla Ates Gulkok and five colleagues untangle a patient whose symptoms closely mimicked a rare autoimmune brain disease but were something else. He had progressive gait trouble, a frozen upward gaze, cognitive decline, feeling sleepy in the daytime, and jerking of all four limbs that he could not control. That picture pointed to anti-IgLON5 disease.
Antibody tests came back negative in blood and spinal fluid. The real answer mixed progressive supranuclear palsy, a movement disorder that worsens over time, with frontal lobe damage from a fall that had caused bleeding in his skull. He grew more alert after spinal fluid drainage, and a standard Parkinson's drug regimen helped further. The case warns that trauma plus degeneration can look just like autoimmune encephalitis.
Catalog record
| CREATOR | Damla Ates Gulkok, Aiswarya Raj, Yakira Mishan, Jessica Bloom, Brittany Zaita, Robert Fekete |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |