Single-cell transcriptomics reveals immune remodeling of the murine lung microenvironment following chronic house dust mite exposure
Han Chang, Liping Zeng, Zahra Malakoutikhah, Chanond A. Nasamran, Scott Herdman, Maripat Corr, Kathleen M. Fisch, Nicholas J. G Webster, Eyal Raz, Samuel Bertin · 2025
Read Single-cell transcriptomics reveals immune remodeling of the murine lung microenvironment following chronic house dust mite exposure by Han Chang, Liping Zeng, Zahra Malakoutikhah, Chanond A. Nasamran, Scott Herdman, Maripat Corr, Kathleen M. Fisch, Nicholas J. G Webster, Eyal Raz, Samuel Bertin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12723145.txt.
Description
Han Chang and co-authors map lung immune changes in mice exposed to house dust mite in a study from two thousand twenty-five. Dust mite is a common trigger of asthma and lasting airway inflammation. The team used single-cell RNA sequencing to see how long exposure reshapes the lung's immune mix.
After five weeks of exposure, many immune cell types had entered and activated in the lungs. A key signal, IL-1β, sustained some cell responses tied to a severe asthma pattern. Mice lacking that signal leaned toward the classic allergic pattern instead. The strength of the mite extract itself also swayed results. The authors stress that context shapes how this signal works.
Catalog record
| CREATOR | Han Chang, Liping Zeng, Zahra Malakoutikhah, Chanond A. Nasamran, Scott Herdman, Maripat Corr, Kathleen M. Fisch, Nicholas J. G Webster, Eyal Raz, Samuel Bertin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |