Identification of subtypes and construction of a predictive model for novel subtypes in severe community-acquired pneumonia based on clinical metagenomics: a multicenter, retrospective cohort study
Shiyi Chen, Yongpo Jiang, Dongqing Lv, Ye Zheng, Ruihai Zhang, Hanzhi Dai, Ziyi Wang, Shuyang Li, Rongbin Qi, Hailing Xu, Yingying Yu, Cailin Xu, Xuanyu Lu, Yinghe Xu, Shengwei Jin, Xiaomai Wu · 2025
Read Identification of subtypes and construction of a predictive model for novel subtypes in severe community-acquired pneumonia based on clinical metagenomics: a multicenter, retrospective cohort study by Shiyi Chen, Yongpo Jiang, Dongqing Lv, Ye Zheng, Ruihai Zhang, Hanzhi Dai, Ziyi Wang, Shuyang Li, Rongbin Qi, Hailing Xu, Yingying Yu, Cailin Xu, Xuanyu Lu, Yinghe Xu, Shengwei Jin, Xiaomai Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722990.txt.
Description
Shiyi Chen and a large team of co-authors wrote this 2025 study on splitting severe lung infection caught outside hospital into truer subtypes. This illness, severe community pneumonia, kills often, and its mix of causes blurs care. Across seventeen centers in China, the team read microbe gene data from lung washings of more than one thousand intensive care patients.
Death within twenty-eight days struck about forty-five percent. Unsupervised learning sorted the patients into two clear groups from their microbe profiles. Slimmed-down models then picked the traits that forecast group membership, and the team built a scoring chart from them. Chart checks covered sharpness, fit, and bedside worth. The authors offer the subtypes and the chart as steps toward care matched to the patient.
Catalog record
| CREATOR | Shiyi Chen, Yongpo Jiang, Dongqing Lv, Ye Zheng, Ruihai Zhang, Hanzhi Dai, Ziyi Wang, Shuyang Li, Rongbin Qi, Hailing Xu, Yingying Yu, Cailin Xu, Xuanyu Lu, Yinghe Xu, Shengwei Jin, Xiaomai Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |