Circuitry correlates of negative urgency and suicidality in schizophrenia spectrum disorders: a LASSO regression study
Tyler Pia, Enna Sanghvi, Mark Shuquan Chen, Thomas Kim, Matthew J. Hoptman, Anthony O. Ahmed · 2025
Read Circuitry correlates of negative urgency and suicidality in schizophrenia spectrum disorders: a LASSO regression study by Tyler Pia, Enna Sanghvi, Mark Shuquan Chen, Thomas Kim, Matthew J. Hoptman, Anthony O. Ahmed (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722959.txt.
Description
Tyler Pia and five colleagues published a psychiatry study in two thousand twenty-five on suicide risk in schizophrenia spectrum disorders. Suicide is common in these conditions. Acting rashly under strong negative emotion, called negative urgency, may help flag risk but is rarely studied with brain data.
Thirty adults classed as high or low risk were analysed with a sparse machine learning method. A first model using symptoms and traits found hostility, guilt, and negative urgency predicted high risk, while abstract thinking difficulty predicted lower risk. Adding brain measures kept hostility and brought in frontal region activity and cingulate thickness. The authors present the combined model as a step toward circuitry-based risk flags. The sample was small.
Catalog record
| CREATOR | Tyler Pia, Enna Sanghvi, Mark Shuquan Chen, Thomas Kim, Matthew J. Hoptman, Anthony O. Ahmed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |