Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide
Rasha A. Tawfiq, Yasmeen M. Attia, Hameis M. Sleem, Mai El-Sayed Ghoneim · 2025
Read Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide by Rasha A. Tawfiq, Yasmeen M. Attia, Hameis M. Sleem, Mai El-Sayed Ghoneim (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722923.txt.
Description
Rasha Tawfiq and co-authors tested two drugs in a 2025 study of liver harm after blood flow returns. When a liver is cut off from blood and then fed again, as in a transplant, the return itself wounds the tissue. Two routes of cell death drive much of that wound, one rust-like and one flame-like.
The team gave rats a drug for each route, alone and as a pair. One drug locks up iron, which feeds the rust-like route, and the other calms the flame-like route. They tracked two gene paths tied to each death route. The paired aim is to shield donor livers and cut post-transplant failure.
Catalog record
| CREATOR | Rasha A. Tawfiq, Yasmeen M. Attia, Hameis M. Sleem, Mai El-Sayed Ghoneim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |