Integrative transcriptomic and single-cell analysis reveals mitochondrial-related gene biomarkers in heart failure with preserved ejection fraction
Hongjun You, Xingying Fan, Jiayu Diao, Fengchao Wu · 2025
Read Integrative transcriptomic and single-cell analysis reveals mitochondrial-related gene biomarkers in heart failure with preserved ejection fraction by Hongjun You, Xingying Fan, Jiayu Diao, Fengchao Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722764.txt.
Description
Hongjun You and co-authors present a 2025 study of a common heart failure type. In this type the heart still pumps with normal force but fills poorly. Faults in the cell power units are closely tied to the problem. The team hunts for key genes that link the two. They mix large gene data sets with single-cell data.
Gene lists from one data set were crossed with power-unit gene lists to find candidates. Three machine learning tools then picked hub genes. The team built a control network around those genes. Single-cell data showed which cell types matter most and how cells signal each other. Checks in other data sets and lab tests backed the picks. The genes may guide new drug ideas and sharper tests. Readers get a full pipeline from raw data to checked markers.
Catalog record
| CREATOR | Hongjun You, Xingying Fan, Jiayu Diao, Fengchao Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |