Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism
Peng Huang, Raminta Venskutonytė, Carter J Wilson, Sara Bsharat, Rashmi B Prasad, Pontus Gourdon, Isabella Artner, Bert L de Groot, Karin Lindkvist-Petersson · 2025
Read Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism by Peng Huang, Raminta Venskutonytė, Carter J Wilson, Sara Bsharat, Rashmi B Prasad, Pontus Gourdon, Isabella Artner, Bert L de Groot, Karin Lindkvist-Petersson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722722.txt.
Description
Cells must keep their levels of hydrogen peroxide in balance, since the chemical both signals and harms. Peng Huang and co-authors explain, in a 2025 study, how a channel protein called AQP3 helps control that flow across the cell membrane. The channel sits in cells such as the insulin-making cells of the pancreas.
Using a microscope method that freezes single particles, the team captured the channel in open and closed shapes. At low acidity the channel stayed open, while acid or peroxide itself swung a loop shut over the pore. In effect, the cargo closes its own gate, which keeps levels from running too high. The finding reveals a self-guarding switch that helps cells hold their chemical balance.
Catalog record
| CREATOR | Peng Huang, Raminta Venskutonytė, Carter J Wilson, Sara Bsharat, Rashmi B Prasad, Pontus Gourdon, Isabella Artner, Bert L de Groot, Karin Lindkvist-Petersson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |