Capicua regulates the survival of Cajal-Retzius cells in the postnatal hippocampus
Zain H Patel, Rebekah van Bruggen, Mi Wang, Qiumin Tan · 2025
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Description
Zain Patel, Rebekah van Bruggen, Mi Wang, and Qiumin Tan study dying brain cells in a 2025 mouse study. Their focus is a set of short-lived nerve cells called Cajal-Retzius cells. These cells fill the young cortex and mostly die off soon after birth. A few last into adult life in the hippocampus, a brain area tied to memory.
The team found that losing a gene called capicua let too many of these cells live on in the adult hippocampus. The effect came from the cells' own loss of the gene, not from their neighbors. Oddly, the extra cells did not change memory-linked acts or seizure risk. Gene reads also showed the cell group is more mixed than once thought. Two factors, FGF1 and BCL2, helped the cells survive.
Catalog record
| CREATOR | Zain H Patel, Rebekah van Bruggen, Mi Wang, Qiumin Tan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |