Early genetic evolution of driver mutations in uveal melanoma
James J Dollar, Christina L Decatur, Ezekiel Weis, Amy C Schefler, Miguel A Materin, Timothy S Fuller, Alison H Skalet, David A Reichstein, Ivana K Kim, Kisha D Piggott, Hakan Demirci, Thomas A Aaberg, Prithvi Mruthyunjaya, Basil K Williams, Eugene Shildkrot, Scott C N Oliver, Devron H Char, Antonio · 2025
Read Early genetic evolution of driver mutations in uveal melanoma by James J Dollar, Christina L Decatur, Ezekiel Weis, Amy C Schefler, Miguel A Materin, Timothy S Fuller, Alison H Skalet, David A Reichstein, Ivana K Kim, Kisha D Piggott, Hakan Demirci, Thomas A Aaberg, Prithvi Mruthyunjaya, Basil K Williams, Eugene Shildkrot, Scott C N Oliver, Devron H Char, Antonio (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722419.txt.
Description
James Dollar, Christina Decatur, Ezekiel Weis, and a wider team wrote this research paper, published in 2025. It traces how the driving gene changes of uveal melanoma, an aggressive eye cancer, unfold early in the tumor's life.
This cancer often spreads before the eye tumor is treated, and tiny tumors are hard to tell from harmless moles. The team profiled the genes of 1,140 tumors, including 131 small ones. Small tumors sat at earlier stages of gene change than large ones. A fifteen-gene test the group had checked before predicted patient survival better than single driver mutations. Its score also flagged small tumors in the act of flipping from a low-risk to a high-risk profile. The authors say the work moves toward a molecular line between a mole and a cancer.
Catalog record
| CREATOR | James J Dollar, Christina L Decatur, Ezekiel Weis, Amy C Schefler, Miguel A Materin, Timothy S Fuller, Alison H Skalet, David A Reichstein, Ivana K Kim, Kisha D Piggott, Hakan Demirci, Thomas A Aaberg, Prithvi Mruthyunjaya, Basil K Williams, Eugene Shildkrot, Scott C N Oliver, Devron H Char, Antonio |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |