STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice
Chi-Wei Lee, Han-Fang Wu, Hsin-Ju Yen, Lun-De Liao, Wei-Chang Mao, Hsun-Shuo Chang, Yih-Fung Chen, Chia-Hsien Lin, Cheng-Ta Li, Hui-Ching Lin · 2025
Read STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice by Chi-Wei Lee, Han-Fang Wu, Hsin-Ju Yen, Lun-De Liao, Wei-Chang Mao, Hsun-Shuo Chang, Yih-Fung Chen, Chia-Hsien Lin, Cheng-Ta Li, Hui-Ching Lin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722381.txt.
Description
Depression harms synaptic plasticity in the prefrontal cortex, weakening the long-term potentiation that learning relies on. Agomelatine, a melatonin receptor agonist and serotonin 2C antagonist, has shown fast action against low mood. The ten authors test how it works in mice put through chronic social defeat stress, a standard model of the illness. They ask whether the repair runs through STAT3 signaling and its control of the enzyme GSK3 beta.
One week of the drug reversed the signs of low mood, restored potentiation, and brought spine density back to normal in the prefrontal cortex. Blocking STAT3 with AG490 undid those gains, tying the gain to STAT3-driven phosphorylation of GSK3 beta. The authors present the STAT3 pathway and the parts farther down its chain as possible targets for the design of fast-acting drugs against low mood.
Catalog record
| CREATOR | Chi-Wei Lee, Han-Fang Wu, Hsin-Ju Yen, Lun-De Liao, Wei-Chang Mao, Hsun-Shuo Chang, Yih-Fung Chen, Chia-Hsien Lin, Cheng-Ta Li, Hui-Ching Lin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |