Biological and computer-aided evaluation of 3-methoxy-13α-estrone-16α-diphenylphosphine oxide as a new antiestrogenic agent
Sándor Bartha, Péter Germán, Noémi Bózsity, László G Puskás, Rita Börzsei, Csaba Hetényi, István Zupkó, Erzsébet Mernyák, Renáta Minorics · 2025
Read Biological and computer-aided evaluation of 3-methoxy-13α-estrone-16α-diphenylphosphine oxide as a new antiestrogenic agent by Sándor Bartha, Péter Germán, Noémi Bózsity, László G Puskás, Rita Börzsei, Csaba Hetényi, István Zupkó, Erzsébet Mernyák, Renáta Minorics (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722357.txt.
Description
Sándor Bartha and co-authors evaluate a new anti-estrogen compound in this 2025 paper. Many breast cancers grow under estrogen receptor signals. The team tested a modified estrone molecule, called EDPO, as a possible blocker.
Computer docking showed the compound fits the receptor binding pocket well. In cell tests it blocked estrogen-driven gene activity and matched a standard drug. It also halted the cell cycle, slowed invasion, and cut migration in breast and throat cancer cells. In rats it blunted estrogen-driven womb growth. In a mouse model of hard-to-treat breast cancer, tumors shrank as the immune setting shifted.
Catalog record
| CREATOR | Sándor Bartha, Péter Germán, Noémi Bózsity, László G Puskás, Rita Börzsei, Csaba Hetényi, István Zupkó, Erzsébet Mernyák, Renáta Minorics |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |