The association between APOA1 (rs5069) gene polymorphism and insulin resistance surrogates and metabolic indices among obese individuals with different glycemic statuses (euglycemic and T2DM)
Nagla Usama, Amr E Ahmed, Salma Mekheimer, Khaled Elhadidy, Mahmoud Farid · 2025
Read The association between APOA1 (rs5069) gene polymorphism and insulin resistance surrogates and metabolic indices among obese individuals with different glycemic statuses (euglycemic and T2DM) by Nagla Usama, Amr E Ahmed, Salma Mekheimer, Khaled Elhadidy, Mahmoud Farid (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722322.txt.
Description
A gene that manages blood fats might also shape diabetes risk, but the evidence is mixed. Nagla Usama and co-authors test one variant of the APOA1 gene in three hundred people. The volunteers form three groups: healthy controls, obese people with normal blood sugar, and obese people with type 2 diabetes. The team measures insulin resistance several ways and types the variant in everyone.
The obese groups, especially those with diabetes, showed far worse insulin resistance and blood fat patterns than controls. One form of the variant was more common among the obese. Yet within each obese group, the gene form made no difference to any metabolic measure. A pattern analysis confirmed that insulin resistance and fats, not the gene, drove the differences. The authors back simple resistance markers for early risk checks.
Catalog record
| CREATOR | Nagla Usama, Amr E Ahmed, Salma Mekheimer, Khaled Elhadidy, Mahmoud Farid |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |