Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease
Lynn K. Win, Guo Cheng, James J. Ashton, Alex Z. Kadhim, Zachary Green, R. Mark Beattie, Sarah Ennis · 2025
Read Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease by Lynn K. Win, Guo Cheng, James J. Ashton, Alex Z. Kadhim, Zachary Green, R. Mark Beattie, Sarah Ennis (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722269.txt.
Description
Lynn Win and colleagues studied in 2025 whether variants in two genes, ERAP1 and ERAP2, help explain autoimmune risk, including inflammatory bowel disease. These genes aid antigen presentation, and their variants were shaped by selection during the Black Death. The team checked patient cohorts from Southampton and the UK Biobank.
In the Southampton group, the burden of impactful ERAP1 variants differed between ulcerative colitis and Crohn's disease patients. In the UK Biobank group, both genes' burdens differed between ulcerative colitis patients and controls. ERAP2 burden also split ulcerative colitis patients by whether they had another autoimmune diagnosis. The authors conclude both genes help predispose people to ulcerative colitis.
Catalog record
| CREATOR | Lynn K. Win, Guo Cheng, James J. Ashton, Alex Z. Kadhim, Zachary Green, R. Mark Beattie, Sarah Ennis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |