Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap
Václav Vopálenský, Michal Sýkora, Zora Mělková, Ivan Barvík, Kamila Horáčková, Tomáš Mašek, Martin Pospíšek · 2025
Read Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap by Václav Vopálenský, Michal Sýkora, Zora Mělková, Ivan Barvík, Kamila Horáčková, Tomáš Mašek, Martin Pospíšek (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722222.txt.
Description
A pox kin virus once gave the world the smallpox shot, and its own notes gave us the cap that crowns most notes in life. Václav Vopálenský and co-authors read that virus's notes one by one in a 2025 study, with a trick that keeps each note's own tail. Their ask: which notes bear the cap, and which do not?
Notes with a long tail of plain A's, built in with no code guide, bore no cap in the living cell. The cap odds fell as the tail grew: half of one A notes bore it, while just one in twenty five of six or more A notes did. Early notes bore caps most; late notes bore them least. The tail, the team say, may steer how the notes are read.
Catalog record
| CREATOR | Václav Vopálenský, Michal Sýkora, Zora Mělková, Ivan Barvík, Kamila Horáčková, Tomáš Mašek, Martin Pospíšek |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |