Irisin activates the AMPK-Beclin1 signaling pathway to regulate pulmonary autophagy induced by CSE + LPS
Zelin Chen, Siyu Wu, Zina Bai, Tongxinwei Sun, Cuiqing Ma, Yahong Chen, Ping Jiang, Aihong Meng · 2025
Read Irisin activates the AMPK-Beclin1 signaling pathway to regulate pulmonary autophagy induced by CSE + LPS by Zelin Chen, Siyu Wu, Zina Bai, Tongxinwei Sun, Cuiqing Ma, Yahong Chen, Ping Jiang, Aihong Meng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722212.txt.
Description
Zelin Chen and co-authors test whether a muscle hormone calms the self-cleaning crisis in lungs stressed by smoke and bacterial toxin, in this 2025 study. Sudden flare-ups drive the damage in chronic obstructive lung disease, and smoking plus infection are their top triggers. Irisin, released from muscle during exercise, is known to ease oxidative stress and inflammation. The question is whether it also steers autophagy, the cell's recycling system, through a known signaling route.
Mice and lung cells were exposed to cigarette smoke extract plus bacterial toxin, with autophagy blocked in some groups. Stains, protein markers, and fluid samples tracked damage and inflammation. The pathway in the title links an energy sensor to a recycling trigger. Pinning down the route gives drug hunters a specific chain to aim at.
Catalog record
| CREATOR | Zelin Chen, Siyu Wu, Zina Bai, Tongxinwei Sun, Cuiqing Ma, Yahong Chen, Ping Jiang, Aihong Meng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |