The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes
Jie Wang, Jianxiong Guo, Nan Li, Zhongzhong Tu, Siyao Liu, Jiaqi Ma, Xinying Zhang, Hairong Cheng, Zhuo Hao, Ye Feng, Shengnan Lv, Guihua Tai, Yifa Zhou, Jiaqi Fu, Changchun Tu, Yan Liu · 2025
Read The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes by Jie Wang, Jianxiong Guo, Nan Li, Zhongzhong Tu, Siyao Liu, Jiaqi Ma, Xinying Zhang, Hairong Cheng, Zhuo Hao, Ye Feng, Shengnan Lv, Guihua Tai, Yifa Zhou, Jiaqi Fu, Changchun Tu, Yan Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722208.txt.
Description
Jie Wang and a large team trace how rabies virus drives brain inflammation in a 2025 study. Rabies causes lethal brain swelling, with many inflammatory signals, but the trigger path was unclear. Star-shaped brain cells, astrocytes, are the main source of those signals in the brain.
A screen found a tagging enzyme, FBXL18, that the virus raises in these cells. The enzyme stabilizes a second protein, which then overactivates a master inflammation switch. Silencing the enzyme cut inflammatory output in tests. The chain gives drug hunters a concrete target in a disease that is almost always fatal once signs appear.
Catalog record
| CREATOR | Jie Wang, Jianxiong Guo, Nan Li, Zhongzhong Tu, Siyao Liu, Jiaqi Ma, Xinying Zhang, Hairong Cheng, Zhuo Hao, Ye Feng, Shengnan Lv, Guihua Tai, Yifa Zhou, Jiaqi Fu, Changchun Tu, Yan Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |