Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain
Yingxin Liu, Yue Wu, Mali Zu, Xingfan Li, Jun Zhang, Danning Wang, Tianjiao Ji, Jiamin Miao · 2025
Read Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain by Yingxin Liu, Yue Wu, Mali Zu, Xingfan Li, Jun Zhang, Danning Wang, Tianjiao Ji, Jiamin Miao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12722206.txt.
Description
Yingxin Liu and co-authors aim a drug carrier at the brain inflammation behind nerve pain, in a 2025 mouse study. Neuropathic pain is driven by chronic crosstalk between two glial cell types. The carrier is a fat bubble decorated with transferrin and phosphatidylserine, loaded with a drug that blocks clumping of the TDP-43 protein. The design slips past the blood-brain barrier and homes to glial cells.
In dishes the carrier kept cells healthy and pushed them toward calm states. In male mice it eased pain behavior, cut inflammatory signals, and quieted the cGAS-STING pathway. The authors pitch the approach as a disease-modifying route, not just symptom relief.
Catalog record
| CREATOR | Yingxin Liu, Yue Wu, Mali Zu, Xingfan Li, Jun Zhang, Danning Wang, Tianjiao Ji, Jiamin Miao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |