Common Genetic Variants in TRIO Are Associated With Autism in Chinese Han Population
Han Shen, Xiaoxuan Sun, Ziqi Wang, Miaomiao Jiang, Jinxin Wang, Tianlan Lu, Weihua Yue, Dai Zhang, Lifang Wang, Jun Li, Qiuhong Xiong · 2025
Read Common Genetic Variants in TRIO Are Associated With Autism in Chinese Han Population by Han Shen, Xiaoxuan Sun, Ziqi Wang, Miaomiao Jiang, Jinxin Wang, Tianlan Lu, Weihua Yue, Dai Zhang, Lifang Wang, Jun Li, Qiuhong Xiong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12721762.txt.
Description
Han Shen and ten co-authors published a genetics study in twenty twenty-five testing common variants of the TRIO gene for links to autism in Chinese Han families. Rare new mutations in TRIO were already tied to autism, since the gene helps neurons migrate and connect. Whether everyday variants also shift risk was unknown.
The team genotyped twelve tagging variants in two hundred thirty-nine families with an autistic child. Three variants showed significant association. Expanding to four hundred twenty-seven families confirmed the signal for all three. The result extends TRIO's role from rare mutations to common variation in this population. It also demonstrates the value of family-based designs, which resist population stratification quirks.
Catalog record
| CREATOR | Han Shen, Xiaoxuan Sun, Ziqi Wang, Miaomiao Jiang, Jinxin Wang, Tianlan Lu, Weihua Yue, Dai Zhang, Lifang Wang, Jun Li, Qiuhong Xiong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |