Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases
Fu Sun, Haochang Li, Bin Gong, Shirong Hui, Ran He, Meijie Yu, Yihao Li, Sheng Yang, Peng Huang, Sreeja Dattachoudhury · 2025
Read Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases by Fu Sun, Haochang Li, Bin Gong, Shirong Hui, Ran He, Meijie Yu, Yihao Li, Sheng Yang, Peng Huang, Sreeja Dattachoudhury (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12721742.txt.
Description
Fu Sun and co-authors use human genetics as a courtroom to test whether depression causes gut disease, gut disease causes depression, or shared genes commit both. Earlier work covered only a slice of the gut. Their 2025 paper takes major depression against eight gastrointestinal diseases at once, with a battery of genetic methods.
Correlation scans found six of the eight gut diseases sharing significant genetic ground with depression. A Mendelian randomization analysis, which uses gene variants as natural experiments, supported direct causal arrows from depression to three conditions. They are acute appendicitis, irritable bowel syndrome, and esophageal ulcer, each raising the odds modestly. Deeper cuts hunted the tissues where the sharing lives and the specific genes and variants both conditions use. The authors give the gut-brain conversation a genetic transcript, distinguishing mere resemblance from cause in at least three pairings.
Catalog record
| CREATOR | Fu Sun, Haochang Li, Bin Gong, Shirong Hui, Ran He, Meijie Yu, Yihao Li, Sheng Yang, Peng Huang, Sreeja Dattachoudhury |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |