Chimeric degraders in neurodegenerative diseases: Challenges and future directions
Hanyuan Zheng, Kun Cui, Jian Mao, You Wan, Jie Zheng · 2025
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Description
Hanyuan Zheng, Kun Cui, Jian Mao, You Wan, and Jie Zheng review, in a 2025 paper, a new class of drugs for brain diseases marked by bad proteins. In Alzheimer's, Parkinson's, and Huntington's disease, misfolded proteins pile up in nerve cells and kill them. Older drugs, such as blockers and antibodies, have had little luck against these hard targets.
The new drugs are chimeras: two-part molecules that grab a target protein with one end and call in the cell's own disposal systems with the other. The review covers the main families, which route proteins to the proteasome, to self-eating pathways, or to lysosomes, plus a family that strips phosphate from tau. It weighs the hurdles each faces and where the field may go.
Catalog record
| CREATOR | Hanyuan Zheng, Kun Cui, Jian Mao, You Wan, Jie Zheng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |