A signature of plasma exosomal miRNAs predict therapeutic efficacy to neoadjuvant immunotherapy in patients with non-small cell lung cancer
Wenyu Zhai, Yaobin Lin, Yuheng Zhou, Qinglin Wang, Zerui Zhao, Shoucheng Feng, Bingyu Rao, Weizhen Sun, Yizhi Wang, Zhigang Zhou, Jing Qin, Hao Long · 2025
Read A signature of plasma exosomal miRNAs predict therapeutic efficacy to neoadjuvant immunotherapy in patients with non-small cell lung cancer by Wenyu Zhai, Yaobin Lin, Yuheng Zhou, Qinglin Wang, Zerui Zhao, Shoucheng Feng, Bingyu Rao, Weizhen Sun, Yizhi Wang, Zhigang Zhou, Jing Qin, Hao Long (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12721357.txt.
Description
Wenyu Zhai and co-authors search blood samples for a gene signal that predicts response to immune therapy given before lung cancer surgery. Lung cancer kills more people than any other cancer, and many cases are found at a locally advanced stage. Tiny parcels shed by cells into blood carry small gene regulators that can shape immune response.
The team studied samples from twenty patients in a trial, half of whom had no cancer left at surgery. Gene reading of the parcels found shifts tied to treatment. A second set of forty-eight samples was then used to build a prediction score. Such a blood test could help select patients for pre-surgery immune treatment.
Catalog record
| CREATOR | Wenyu Zhai, Yaobin Lin, Yuheng Zhou, Qinglin Wang, Zerui Zhao, Shoucheng Feng, Bingyu Rao, Weizhen Sun, Yizhi Wang, Zhigang Zhou, Jing Qin, Hao Long |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |