Exosomal miR-493-3p Promote the Secretion of CXCL10 by Suppressing Keratinocyte Autophagy in Vitiligo
Zeqi Shi, Dong Li, Ri Zhang, Ying Zeng, Wenqi Liu, Yunhua Deng · 2025
Read Exosomal miR-493-3p Promote the Secretion of CXCL10 by Suppressing Keratinocyte Autophagy in Vitiligo by Zeqi Shi, Dong Li, Ri Zhang, Ying Zeng, Wenqi Liu, Yunhua Deng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12720970.txt.
Description
Zeqi Shi and co-authors trace a tiny RNA signal that helps drive the skin disease vitiligo, in a 2025 paper. Vitiligo destroys the pigment cells of the skin, leaving pale patches. Skin surface cells, called keratinocytes, seem to take part in the attack, partly by calling in immune cells. The team asked how those surface cells change in diseased skin and what flips the switch.
Reworking public single-cell data, they found the surface cells' self-cleaning process, autophagy, runs weak in lesions. A small RNA carried in tiny cell parcels, miR-493-3p, rose to the top as a suspect. Lab tests with blots, chemical assays, and stained images confirmed that this RNA throttles the self-cleaning. With cleaning suppressed, the cells release more of an immune call signal. The chain gives drug hunters a fresh target in a stubborn disease.
Catalog record
| CREATOR | Zeqi Shi, Dong Li, Ri Zhang, Ying Zeng, Wenqi Liu, Yunhua Deng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |