Comparison of 2-hour versus 4-hour hemoadsorption combined with hemodialysis (HAHD): an in vitro and prospective clinical evaluation

Description

Wei Lu and Gengru Jiang test whether doubling a blood-cleaning session from two hours to four actually clears more toxins. The treatment pairs standard dialysis with a filter that adsorbs middle-sized molecules, used for people on long-term dialysis whose blood carries inflammatory waste. Bench tests in a recirculating rig tracked three target substances over four hours, and then 92 stable patients each received one session of either length.

Removal kept climbing with time in the rig, reaching about 93 percent for two targets at four hours. In patients, the longer session cleared clearly more of two inflammatory signals and two middle toxins, with the tumor necrosis factor cut roughly doubling. Both lengths were tolerated well, with no safety concerns. The authors conclude the four-hour version suits patients with heavy inflammatory burdens, trading chair time for cleaner blood.

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Source: https://europepmc.org/articles/PMC12720666