Atosiban-conjugated 3WJ-pRNA nanoparticles delivering GAS1-enhanced extracellular vesicles: targeting the decidua to combat recurrent miscarriage
Yuan-Xing Li, Si-Qi Wei, Peng-Sheng Zheng · 2025
Read Atosiban-conjugated 3WJ-pRNA nanoparticles delivering GAS1-enhanced extracellular vesicles: targeting the decidua to combat recurrent miscarriage by Yuan-Xing Li, Si-Qi Wei, Peng-Sheng Zheng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12720446.txt.
Description
Yuan-Xing Li, Si-Qi Wei, and Peng-Sheng Zheng pursue a gene, GAS1, that may help the uterus hold a pregnancy and combat recurrent miscarriage. Repeated pregnancy loss often traces to dysfunction of the decidua, the uterine lining, and current care leans on immune and hormone therapies that miss that root. GAS1 regulates the making of extracellular vesicles, tiny sacs that decidual cells use to communicate. Their 2025 study maps that communication and builds a way to boost it.
Cells low in GAS1 produced poor vesicles. Vesicles from GAS1-rich cells carried more of the protein and helped the embryo adhere, trophoblasts migrate, and blood vessels form. The team loaded the enriched vesicles onto RNA nanoparticles targeted to the decidua. In mice prone to recurrent loss, the treatment restored the lining's order and reduced pup loss. The route is needle-free and targeted, a fresh approach for care.
Catalog record
| CREATOR | Yuan-Xing Li, Si-Qi Wei, Peng-Sheng Zheng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |