Association of cognitive impairment with adverse cardiovascular outcomes: the mediating role of modifiable risk factors in a prospective cohort study
Le Zhou, Zejun Yang, Lan Ren, Gaifeng Hu, Jue Wang, Sitong Li, Xiaodong Peng, Manlin Zhao, Qifan Li, Zixu Zhao, Mingxiao Li, Meiqi Zhao, Ting Shen, Zhixian Wang, Enze Li, Yize Zhao, Ning Zhou, Caihua Sang, Chang-Sheng Ma, Jianzeng Dong, Yiwei Lai, Liu He, Jingrui Zhang, Wen-Yu Wang, Xin Du, Ribo Tan · 2025
Read Association of cognitive impairment with adverse cardiovascular outcomes: the mediating role of modifiable risk factors in a prospective cohort study by Le Zhou, Zejun Yang, Lan Ren, Gaifeng Hu, Jue Wang, Sitong Li, Xiaodong Peng, Manlin Zhao, Qifan Li, Zixu Zhao, Mingxiao Li, Meiqi Zhao, Ting Shen, Zhixian Wang, Enze Li, Yize Zhao, Ning Zhou, Caihua Sang, Chang-Sheng Ma, Jianzeng Dong, Yiwei Lai, Liu He, Jingrui Zhang, Wen-Yu Wang, Xin Du, Ribo Tan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12719892.txt.
Description
Le Zhou and co-authors study, in twenty twenty-five, how cognitive impairment links to heart and vessel outcomes in a large British cohort. They used UK Biobank, a population study, with more than one hundred fifty thousand people free of heart disease and dementia at the start. Mean age was about fifty-six, and men were a minority. Follow-up ran for about thirteen years. Outcomes were cardiovascular death and a composite of cardiovascular events, modeled with survival methods and mediation analysis.
About fifteen percent had cognitive impairment. That group carried more lifestyle, metabolic, and psychological risks, except for alcohol use. Impairment linked to a notably higher risk of cardiovascular death and a slightly higher risk of the composite outcome. The study quantifies how much uncontrolled risk factors mediate that link.
Catalog record
| CREATOR | Le Zhou, Zejun Yang, Lan Ren, Gaifeng Hu, Jue Wang, Sitong Li, Xiaodong Peng, Manlin Zhao, Qifan Li, Zixu Zhao, Mingxiao Li, Meiqi Zhao, Ting Shen, Zhixian Wang, Enze Li, Yize Zhao, Ning Zhou, Caihua Sang, Chang-Sheng Ma, Jianzeng Dong, Yiwei Lai, Liu He, Jingrui Zhang, Wen-Yu Wang, Xin Du, Ribo Tan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |