A Systems Biology and Drug Repositioning Approach for the Analysis of Mutual Genes Between Celiac Disease and Irritable Bowel Syndrome
Haitham Al-Madhagi · 2025
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Description
Haitham Al-Madhagi uses computer-based systems biology in a 2025 paper to compare celiac disease and irritable bowel syndrome. Both cause gut symptoms and involve the immune system, but their shared gene roots are unclear. He mined public gene datasets from both diseases to find the overlap.
The search found 439 shared genes. He mapped what those genes do, which switches and small regulators control them, and how their proteins interact, then picked the hub genes at the web's center. Last, he screened approved drugs against the top hub's protein shape. Old drugs that fit could be repurposed to treat one or both diseases.
Catalog record
| CREATOR | Haitham Al-Madhagi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |