Severe Dry Cough Followed by Eosinophilia Without Pulmonary Infiltrates After Dupilumab Treatment in Patients with Severe Asthma: A Series of Five Cases
Yan Chen, Jiaxing Xie · 2025
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Description
Yan Chen and Jiaxing Xie report five asthma patients who developed a severe dry cough after treatment with the drug dupilumab, in a 2025 case series. The drug often causes a mild, passing rise in eosinophils, a type of white blood cell. Rarely, that rise comes with lung inflammation. These five cases were different: scans and exams showed no lung inflammation at all, yet the cough was harsh.
The patients, treated at a Guangzhou breathing institute, were sixty-six years old on average. The cough began after one to eleven drug courses, as eosinophil counts climbed high. All five still hit their best-ever breathing test scores. Four patients settled with a short steroid course, and one with cough medicine alone. The authors say doctors should know this cough can appear without pneumonia, and that it answers well to simple treatment.
Catalog record
| CREATOR | Yan Chen, Jiaxing Xie |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |