Downregulation of TRPV4 and LRRC8A in Crystalline Lenses of Diabetic Patients May Contribute to Cataractogenesis
Jesús Silvestre Albert-Garay, José Alberto Icazbalceta de la Peña, Alan E Medina-Arellano, Roberto González-Salinas, Lenin David Ochoa-de la Paz · 2025
Read Downregulation of TRPV4 and LRRC8A in Crystalline Lenses of Diabetic Patients May Contribute to Cataractogenesis by Jesús Silvestre Albert-Garay, José Alberto Icazbalceta de la Peña, Alan E Medina-Arellano, Roberto González-Salinas, Lenin David Ochoa-de la Paz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12719619.txt.
Description
Jesús Albert-Garay and co-authors compare water-channel proteins in the eye lenses of patients with and without type 2 diabetes. Diabetes raises cataract risk, and sugar alcohol building up inside lens cells can upset their water balance. Two channels, TRPV4 and LRRC8A, help lens cells hold their volume steady.
Using lens capsules from fifty cataract surgeries, split between diabetic and non-diabetic patients, the team measured three channel proteins by fluorescence. Diabetic lenses showed worse cataracts and lower levels of the two volume channels. The authors propose that losing these channels weakens the lens's defenses, helping explain why diabetic cataracts form earlier and faster.
Catalog record
| CREATOR | Jesús Silvestre Albert-Garay, José Alberto Icazbalceta de la Peña, Alan E Medina-Arellano, Roberto González-Salinas, Lenin David Ochoa-de la Paz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |