Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer
Jie Gong, Dianyu Sun, Yuxin Zheng, Chuwen Mao, Bowen Yu, Xiaogang Li, Yanhua Xuan · 2025
Read Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer by Jie Gong, Dianyu Sun, Yuxin Zheng, Chuwen Mao, Bowen Yu, Xiaogang Li, Yanhua Xuan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12719610.txt.
Description
Gong and co-authors study how the plant compound dauricine affects bladder cancer through the immune cells around the tumor. Macrophages of the M2 type help tumors grow and spread. Dauricine, from a Chinese herb, can slow several tumor types. Its effect on the tumor setting was unclear. Lab tests showed dauricine blocked M2 shifting in macrophages. It also pushed those cells toward an iron-driven form of cell death.
The effect ran through a protein called HCK and its downstream partner IDO1. Cancer cells under treatment also showed more ferritin breakdown. Together the changes slowed tumor progress in the models. The work names a pathway that future bladder cancer drugs might target.
Catalog record
| CREATOR | Jie Gong, Dianyu Sun, Yuxin Zheng, Chuwen Mao, Bowen Yu, Xiaogang Li, Yanhua Xuan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |