FOSL1-PRMT1 transcriptional-epigenetic circuit promotes glioblastoma radioresistance via calcyphosine-mediated DNA repair and invasion
Yating Zhang, Jiajia Tian, Shuai Wu, Yiting Zhou, Zhongyuan Bao, Yi Zhu, Peng Wang, Zixiang Liu, Pengpeng Li, Zhenxing Tao, Zengli Miao, Xiaojie Lu, Xudong Zhao · 2025
Read FOSL1-PRMT1 transcriptional-epigenetic circuit promotes glioblastoma radioresistance via calcyphosine-mediated DNA repair and invasion by Yating Zhang, Jiajia Tian, Shuai Wu, Yiting Zhou, Zhongyuan Bao, Yi Zhu, Peng Wang, Zixiang Liu, Pengpeng Li, Zhenxing Tao, Zengli Miao, Xiaojie Lu, Xudong Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12719381.txt.
Description
Yating Zhang and twelve co-authors trace, in 2025 work, a gene loop that lets a fierce brain tumour shrug off rays. Ray care fails oft in this tumour, and cells come back. One switch protein ran high in returned cases and poor outlooks. Hushing it made cells ray-shy, slowed DNA repair, and curbed their push into new ground.
The switch holds a tag enzyme firm; the pair then tags both a DNA wrap and a cord protein, and wakes a calcium-sense gene. That gene is the workhorse of the loop: it fires both main DNA repair paths at once. In mice, cuts to the loop — by gene or drug — made tumours ray-shy and less bold. A new drug mark is named.
Catalog record
| CREATOR | Yating Zhang, Jiajia Tian, Shuai Wu, Yiting Zhou, Zhongyuan Bao, Yi Zhu, Peng Wang, Zixiang Liu, Pengpeng Li, Zhenxing Tao, Zengli Miao, Xiaojie Lu, Xudong Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |