Epigenetic crosstalk between uric acid and vascular health: a role for extracellular vesicles
Concetta Schiano, Claudio Napoli · 2025
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Description
Concetta Schiano and Claudio Napoli write a letter linking high uric acid to early artery disease through tiny parcels sent between cells. They respond to a study that found shifts in gene control marks in blood cells of young men with high uric acid or early artery changes. The shifts appeared apart from standard risk factors.
The letter proposes that small parcels called vesicles carry the control tools from cell to cell. Past work by the authors showed such parcels from heart patients can add new gene marks to vessel cells. They outline tests to check the cargo of parcels in these men. If confirmed, the path could explain how high uric acid quietly reshapes vessel health.
Catalog record
| CREATOR | Concetta Schiano, Claudio Napoli |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |