Potentiation of ryanodine receptor–mediated calcium release by MAPK is responsible for epidermal transformation and carcinogenesis
Pengcheng Wang, Kristan H. Cleveland, Ayaz Shahid, Chathurika Rathnayaka, Farideh Amirrad, Zhenpeng Song, John Paul Estillore, Ruiwu Wang, Thomas G. Back, S. R. Wayne Chen, Ying Huang · 2025
Read Potentiation of ryanodine receptor–mediated calcium release by MAPK is responsible for epidermal transformation and carcinogenesis by Pengcheng Wang, Kristan H. Cleveland, Ayaz Shahid, Chathurika Rathnayaka, Farideh Amirrad, Zhenpeng Song, John Paul Estillore, Ruiwu Wang, Thomas G. Back, S. R. Wayne Chen, Ying Huang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12718376.txt.
Description
Pengcheng Wang and co-authors published a research paper in 2025 on a calcium channel in skin cells and its part in turning normal growth into cancer. A growth signal switches on a pathway that, the team found, also boosts this channel, so cells release more calcium. A heart drug known to calm the overactive channel blocks the change, which hinted at the link.
In mouse skin cells, growth signals and sun-like rays both raised the channel's activity and the calcium flow. Adding channel openers pushed cells toward change, while blockers and calcium sponges stopped it. Silencing the channel's genes removed the drug's protective effect. The work names the channel as a driver worth targeting in skin cancer prevention.
Catalog record
| CREATOR | Pengcheng Wang, Kristan H. Cleveland, Ayaz Shahid, Chathurika Rathnayaka, Farideh Amirrad, Zhenpeng Song, John Paul Estillore, Ruiwu Wang, Thomas G. Back, S. R. Wayne Chen, Ying Huang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |