Spermidine Alleviates Sepsis-Induced Acute Lung Injury through AMPK-Mediated Improvement of Necroptosis
Bingqing Ye, Yuan Jin, Shansong Hu, Yiwei Shao, Qiaoyu Yang, Han Wu, Zhicheng Liu · 2025
Read Spermidine Alleviates Sepsis-Induced Acute Lung Injury through AMPK-Mediated Improvement of Necroptosis by Bingqing Ye, Yuan Jin, Shansong Hu, Yiwei Shao, Qiaoyu Yang, Han Wu, Zhicheng Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12718291.txt.
Description
Bingqing Ye and co-authors test spermidine, a natural cell compound, against sepsis lung harm in rats in 2025. Sepsis can flood the lungs and drive death, and spermidine is known for calm effects on swelling. Rats with a gut-based sepsis model got the compound while lung harm and survival were tracked.
Treated rats lived more, with less lung harm and lower swelling signals. Tests point to a cell energy switch, AMPK, as the target the compound hits. Blocking that switch wiped out the gains, and the path runs through a cell death route the compound holds back.
Catalog record
| CREATOR | Bingqing Ye, Yuan Jin, Shansong Hu, Yiwei Shao, Qiaoyu Yang, Han Wu, Zhicheng Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |