Does hypoxemia aggravate sepsis-associated acute kidney injury? Integrated clinical and experimental evidence
Haoyun Mao, Jiayue Xu, Yueniu Zhu, Xiangmei Kong, Jiru Li, Xiaodong Zhu, Yaya Xu · 2025
Read Does hypoxemia aggravate sepsis-associated acute kidney injury? Integrated clinical and experimental evidence by Haoyun Mao, Jiayue Xu, Yueniu Zhu, Xiangmei Kong, Jiru Li, Xiaodong Zhu, Yaya Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12718267.txt.
Description
Haoyun Mao and colleagues published a 2025 study asking whether low blood oxygen worsens kidney injury in sepsis. Sepsis often damages the kidneys. Low oxygen is common in these patients too. The team analyzed thousands of intensive care records. Mice experiments tested the mechanism directly.
Patients with lower oxygen looked sicker at first glance. Careful adjustment removed the independent link. Kidney markers matched that pattern. Mouse groups combined sepsis, low oxygen, or both. Tissue and protein measures tracked the injury. The combined evidence argues low oxygen is a warning sign. It may not itself drive the kidney damage.
Catalog record
| CREATOR | Haoyun Mao, Jiayue Xu, Yueniu Zhu, Xiangmei Kong, Jiru Li, Xiaodong Zhu, Yaya Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |