Progress in Research on Macrophage Polarization Mechanisms and Targeted Therapies in Staphylococcus aureus Infections
Wentong Yan, Xupeng Li, Sen Xu, Haibang Pan, Bo Wang, Zhaoyang Zeng, Yuhong Shi · 2025
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Description
Macrophages can switch between attack mode and repair mode. That balance decides how Staphylococcus aureus infections end. Wentong Yan and co-authors review how the bacterium and the host fight over the switch. Early attack-mode cells kill bacteria but can damage tissue if they overshoot. Repair-mode cells calm inflammation and heal, yet can shelter bacteria in chronic infections. Signals from the pathogen, metabolism, and epigenetics all steer the balance.
New therapies try to steer it deliberately, using stem cells, exosomes, nanocarriers, and natural medicines. Evidence so far is mostly from animals. The authors flag patient differences and translation to the clinic as the open problems.
Catalog record
| CREATOR | Wentong Yan, Xupeng Li, Sen Xu, Haibang Pan, Bo Wang, Zhaoyang Zeng, Yuhong Shi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |