Integrating Network Pharmacology and Experimental Validation to Investigate the Action Mechanism of Allicin in Atherosclerosis
Shuaikai Wu, Tingting Liu, Mingjin Weng, Yuping Zhou, Lijing Ye, Suyan Ruan, Dongmei Tang, Qiong Zhong, Lili Liu, Guojun Zhao · 2025
Read Integrating Network Pharmacology and Experimental Validation to Investigate the Action Mechanism of Allicin in Atherosclerosis by Shuaikai Wu, Tingting Liu, Mingjin Weng, Yuping Zhou, Lijing Ye, Suyan Ruan, Dongmei Tang, Qiong Zhong, Lili Liu, Guojun Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717827.txt.
Description
Shuaikai Wu and co-authors combine computer prediction with lab tests to pin down how allicin, garlic's signature compound, fights atherosclerosis. Allicin helps in several diseases, but its targets in clogged arteries were vague, limiting drug development. Network pharmacology first maps the compound's likely protein partners and pathways.
Docking simulations checked the fit between allicin and its candidate targets. Bench experiments then measured cell death in vessel tissue, plaque size, and blood lipids in treated models, with staining and fluorescence confirming the mechanism. The two-pronged design filters computer guesses through reality. Clarifying how a food-derived molecule works could seed new artery drugs.
Catalog record
| CREATOR | Shuaikai Wu, Tingting Liu, Mingjin Weng, Yuping Zhou, Lijing Ye, Suyan Ruan, Dongmei Tang, Qiong Zhong, Lili Liu, Guojun Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |